Altered cellular redox status , sirtuin abundance and clock gene expression in a 1 mouse model of developmentally
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چکیده
Altered cellular redox status, sirtuin abundance and clock gene expression in a 1 mouse model of developmentally primed NASH 2 3 Kimberley D Bruce, Dawid Szczepankiewicz, Kiran K Sihota, Manoj Ravindraanandan, 4 Hugh Thomas, Karen A Lillycrop, Graham C Burdge, Mark A Hanson, Christopher D 5 Byrne, Felino R Cagampang 6 Institute of Developmental Sciences, Faculty of Medicine, University of Southampton, 7 Southampton General Hospital, Southampton, UK 8 University of Colorado, Anschutz Medical Campus, Endocrinology, Metabolism and 9 Diabetes, Aurora, USA 10 Poznań University of Life Sciences, Department of Animal Physiology and Biochemistry, 11 Poznań, Poland 12 Centre for Biological sciences, Institute of Developmental Sciences, Faculty of Natural and 13 Environmental Sciences, University of Southampton, Southampton, UK 14
منابع مشابه
Altered cellular redox status, sirtuin abundance and clock gene expression in a mouse model of developmentally primed NASH☆
BACKGROUND We have previously shown that high fat (HF) feeding during pregnancy primes the development of non-alcoholic steatohepatits (NASH) in the adult offspring. However, the underlying mechanisms are unclear. AIMS Since the endogenous molecular clock can regulate hepatic lipid metabolism, we investigated whether exposure to a HF diet during development could alter hepatic clock gene expr...
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